The role of β-catenin in Bcr/Abl negative myeloproliferative neoplasms: an immunohistochemical study
A Geduk, EB Atesoglu, P Tarkun, O Mehtap… - … Myeloma and Leukemia, 2015 - Elsevier
A Geduk, EB Atesoglu, P Tarkun, O Mehtap, A Hacihanefioglu, ET Demirsoy, C Baydemir
Clinical Lymphoma Myeloma and Leukemia, 2015•ElsevierIntroduction β-Catenin is a multifunctional protein that acts as a central effector molecule in
the Wnt signaling pathway. Aberrant activation of the Wnt/β-catenin signaling pathway
causes various diseases including cancer. In this study we evaluated β-catenin expression
in bcr/abl-negative myeloproliferative neoplasms (MPNs). Materials and Methods The
expression of β-catenin was evaluated in bone marrow using immunohistochemical
methods in 66 patients with bcr/abl-negative myeloproliferative neoplasms (MPNs) and in 30 …
the Wnt signaling pathway. Aberrant activation of the Wnt/β-catenin signaling pathway
causes various diseases including cancer. In this study we evaluated β-catenin expression
in bcr/abl-negative myeloproliferative neoplasms (MPNs). Materials and Methods The
expression of β-catenin was evaluated in bone marrow using immunohistochemical
methods in 66 patients with bcr/abl-negative myeloproliferative neoplasms (MPNs) and in 30 …
Introduction
β-Catenin is a multifunctional protein that acts as a central effector molecule in the Wnt signaling pathway. Aberrant activation of the Wnt/β-catenin signaling pathway causes various diseases including cancer. In this study we evaluated β-catenin expression in bcr/abl-negative myeloproliferative neoplasms (MPNs).
Materials and Methods
The expression of β-catenin was evaluated in bone marrow using immunohistochemical methods in 66 patients with bcr/abl-negative myeloproliferative neoplasms (MPNs) and in 30 healthy control subjects. Immunreactive score (IRS; staining intensity × percentage of positive stained cells) was used for the evaluation of the cell staining reaction.
Results
IRS of megakaryocytes (IRSmega) was higher in essential thrombocytemia (ET) compared with the control group (P = .022) and primary myelofibrosis (PMF; P = .001). IRS of vascular endothelial cells (IRSvas) was higher in the bcr/abl negative MPN compared with the control group (P = .024). Also, IRSvas was higher in the PMF compared with the control group (P = .001), policythemia vera (PV; P = .005), and ET (P = .006). A positive correlation was detected between IRSmega and platelet counts (P = .019).
Conclusion
Results of this study suggest that the Wnt/β-catenin signaling pathway has a role in the angiogenesis of PMF and in the thrombopoiesis of PV and ET. Hence, targeting the Wnt/β-catenin signaling pathway could open new avenues for novel therapeutic approaches in bcr/abl-negative MPNs.
Elsevier
