[HTML][HTML] Classical nuclear localization signals: definition, function, and interaction with importin α
The best understood system for the transport of macromolecules between the cytoplasm and
the nucleus is the classical nuclear import pathway. In this pathway, a protein containing a
classical basic nuclear localization signal (NLS) is imported by a heterodimeric import
receptor consisting of the β-karyopherin importin β, which mediates interactions with the
nuclear pore complex, and the adaptor protein importin α, which directly binds the classical
NLS. Here we review recent studies that have advanced our understanding of this pathway …
the nucleus is the classical nuclear import pathway. In this pathway, a protein containing a
classical basic nuclear localization signal (NLS) is imported by a heterodimeric import
receptor consisting of the β-karyopherin importin β, which mediates interactions with the
nuclear pore complex, and the adaptor protein importin α, which directly binds the classical
NLS. Here we review recent studies that have advanced our understanding of this pathway …
