[HTML][HTML] A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia
MJ Huang, Y Cheng, CR Liu, S Lin, HE Liu - Experimental hematology, 2006 - Elsevier
OBJECTIVE: The protooncogene c-Myc plays an important role in the control of cell
proliferation, apoptosis, and differentiation, and its aberrant expression is frequently seen in
multiple human cancers, including acute myeloid leukemia (AML). As c-Myc heterodimerizes
with Max to transactivate downstream target genes in leukemogenesis. Inhibition of the c-
Myc/Max heterodimerization by the recently identified small-molecule compound, 10058-F4,
might be a novel antileukemic strategy. MATERIALS AND METHODS: HL-60, U937, and …
proliferation, apoptosis, and differentiation, and its aberrant expression is frequently seen in
multiple human cancers, including acute myeloid leukemia (AML). As c-Myc heterodimerizes
with Max to transactivate downstream target genes in leukemogenesis. Inhibition of the c-
Myc/Max heterodimerization by the recently identified small-molecule compound, 10058-F4,
might be a novel antileukemic strategy. MATERIALS AND METHODS: HL-60, U937, and …
