Crystal structure of a human plasma membrane phospholipid flippase
H Nakanishi, K Irie, K Segawa, K Hasegawa… - Journal of Biological …, 2020 - ASBMB
ATP11C, a member of the P4-ATPase flippase, translocates phosphatidylserine from the
outer to the inner plasma membrane leaflet, and maintains the asymmetric distribution of
phosphatidylserine in the living cell. We present the crystal structures of a human plasma
membrane flippase, ATP11C–CDC50A complex, in a stabilized E2P conformation. The
structure revealed a deep longitudinal crevice along transmembrane helices continuing from
the cell surface to the phospholipid occlusion site in the middle of the membrane. We …
outer to the inner plasma membrane leaflet, and maintains the asymmetric distribution of
phosphatidylserine in the living cell. We present the crystal structures of a human plasma
membrane flippase, ATP11C–CDC50A complex, in a stabilized E2P conformation. The
structure revealed a deep longitudinal crevice along transmembrane helices continuing from
the cell surface to the phospholipid occlusion site in the middle of the membrane. We …
