[HTML][HTML] The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane
K Segawa, S Kurata, S Nagata - Journal of Biological Chemistry, 2018 - ASBMB
Flippases are enzymes that translocate phosphatidylserine (PtdSer) and
phosphatidylethanolamine (PtdEtn) from the outer to the inner leaflet in the lipid bilayer of
the plasma membrane, leading to the asymmetric distribution of aminophospholipids in the
membrane. One mammalian phospholipid flippase at the plasma membrane is ATP11C, a
type IV P-type ATPase (P4-ATPase) that forms a heterocomplex with the transmembrane
protein CDC50A. However, the structural features in CDC50A that support the function of …
phosphatidylethanolamine (PtdEtn) from the outer to the inner leaflet in the lipid bilayer of
the plasma membrane, leading to the asymmetric distribution of aminophospholipids in the
membrane. One mammalian phospholipid flippase at the plasma membrane is ATP11C, a
type IV P-type ATPase (P4-ATPase) that forms a heterocomplex with the transmembrane
protein CDC50A. However, the structural features in CDC50A that support the function of …
