Serotonin stimulates mouse skeletal muscle 6-phosphofructo-1-kinase through tyrosine-phosphorylation of the enzyme altering its intracellular localization
WS Coelho, KC Costa, M Sola-Penna - Molecular genetics and metabolism, 2007 - Elsevier
Serotonin (5-HT) is a hormone implicated in the regulation of many physiological and
pathological events. One of its most intriguing properties is the ability to up-regulate mitosis.
Moreover, it has been shown that 5-HT stimulate glucose uptake on skeletal muscle,
suggesting that 5-HT may regulate glucose metabolism of peripheric tissues. Here we
demonstrate that 5-HT stimulates skeletal muscle 6-phosphofructo-1-kinase (PFK) activity in
a dose–response manner, through 5-HT2A receptor subtype. Maximal activation of the …
pathological events. One of its most intriguing properties is the ability to up-regulate mitosis.
Moreover, it has been shown that 5-HT stimulate glucose uptake on skeletal muscle,
suggesting that 5-HT may regulate glucose metabolism of peripheric tissues. Here we
demonstrate that 5-HT stimulates skeletal muscle 6-phosphofructo-1-kinase (PFK) activity in
a dose–response manner, through 5-HT2A receptor subtype. Maximal activation of the …
