In the central nervous system (CNS), cyclic adenosine monophosphate (cAMP) plays a
critical role in numerous, often concurrent, neuronal functions including survival, growth,
differentiation and synaptogenesis. Elucidating the mechanisms by which this ubiquitous
secondary messenger influences these processes is crucial to understanding why CNS
neurons fail to regenerate after injury or in disease. Several survival and growth promoting
pathways have been linked to cAMP signaling in neurons, including mitogen-activated …