[HTML][HTML] Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
CD Heer, DJ Sanderson, LS Voth… - Journal of Biological …, 2020 - ASBMB
Poly (ADP-ribose) polymerase (PARP) superfamily members covalently link either a single
ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the source of ADPR.
Although the well-known poly (ADP-ribosylating)(PARylating) PARPs primarily function in
the DNA damage response, many noncanonical mono (ADP-ribosylating)(MARylating)
PARPs are associated with cellular antiviral responses. We recently demonstrated robust up-
regulation of several PARPs following infection with murine hepatitis virus (MHV), a model …
ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the source of ADPR.
Although the well-known poly (ADP-ribosylating)(PARylating) PARPs primarily function in
the DNA damage response, many noncanonical mono (ADP-ribosylating)(MARylating)
PARPs are associated with cellular antiviral responses. We recently demonstrated robust up-
regulation of several PARPs following infection with murine hepatitis virus (MHV), a model …