[HTML][HTML] Autophagy and rheumatoid arthritis: current knowledges and future perspectives
M Vomero, C Barbati, T Colasanti, C Perricone… - Frontiers in …, 2018 - frontiersin.org
M Vomero, C Barbati, T Colasanti, C Perricone, L Novelli, F Ceccarelli, FR Spinelli…
Frontiers in Immunology, 2018•frontiersin.orgAutophagy is a degradation mechanism by which cells recycle cytoplasmic components to
generate energy. By influencing lymphocyte development, survival, and proliferation,
autophagy regulates the immune responses against self and non-self antigens.
Deregulation of autophagic pathway has recently been implicated in the pathogenesis of
several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy
seems to be involved in the generation of citrullinated peptides, and also in apoptosis …
generate energy. By influencing lymphocyte development, survival, and proliferation,
autophagy regulates the immune responses against self and non-self antigens.
Deregulation of autophagic pathway has recently been implicated in the pathogenesis of
several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy
seems to be involved in the generation of citrullinated peptides, and also in apoptosis …
Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens. Deregulation of autophagic pathway has recently been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis (RA). Indeed, autophagy seems to be involved in the generation of citrullinated peptides, and also in apoptosis resistance in RA. In this review, we summarize the current knowledge on the role of autophagy in RA and discuss the possibility of a clinical application of autophagy modulation in this disease.
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