Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone
K Tekirdag, AM Cuervo - Journal of Biological Chemistry, 2018 - ASBMB
A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for
degradation through autophagy. Here, we focus on two autophagic pathways, the
chaperone-mediated autophagy and the endosomal microautophagy that rely on the
cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage
of proteins for degradation by different proteolytic systems, the common characteristic
shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino …
degradation through autophagy. Here, we focus on two autophagic pathways, the
chaperone-mediated autophagy and the endosomal microautophagy that rely on the
cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage
of proteins for degradation by different proteolytic systems, the common characteristic
shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino …