Interferon-induced transmembrane protein 3 genetic variant rs12252-C associated with disease severity in coronavirus disease 2019
Y Zhang, L Qin, Y Zhao, P Zhang, B Xu… - The Journal of …, 2020 - academic.oup.com
Y Zhang, L Qin, Y Zhao, P Zhang, B Xu, K Li, L Liang, C Zhang, Y Dai, Y Feng, J Sun, Z Hu…
The Journal of infectious diseases, 2020•academic.oup.comA major unanswered question in the current global coronavirus disease 2019 (COVID-19)
outbreak is why severe disease develops in a small minority of infected individuals. In the
current article, we report that homozygosity for the C allele of rs12252 in the interferon-
induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in
an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the
opportunity for early targeted intervention in at-risk individuals.
outbreak is why severe disease develops in a small minority of infected individuals. In the
current article, we report that homozygosity for the C allele of rs12252 in the interferon-
induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in
an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the
opportunity for early targeted intervention in at-risk individuals.
Abstract
A major unanswered question in the current global coronavirus disease 2019 (COVID-19) outbreak is why severe disease develops in a small minority of infected individuals. In the current article, we report that homozygosity for the C allele of rs12252 in the interferon-induced transmembrane protein 3 (IFITM3) gene is associated with more severe disease in an age-dependent manner. This supports a role for IFITM3 in disease pathogenesis and the opportunity for early targeted intervention in at-risk individuals.
Oxford University Press