[HTML][HTML] γδ T cells: crosstalk between microbiota, chronic inflammation, and colorectal cancer

Y Yang, C Xu, D Wu, Z Wang, P Wu, L Li… - Frontiers in …, 2018 - frontiersin.org
Y Yang, C Xu, D Wu, Z Wang, P Wu, L Li, J Huang, F Qiu
Frontiers in Immunology, 2018frontiersin.org
Increasing evidence suggests that intestinal microbiota dysbiosis and chronic inflammation
contribute to colorectal cancer (CRC) development. γδ T cells represent a major innate
immune cell population in the intestinal epithelium that is involved in the maintenance of gut
homeostasis, inflammation regulation, and carcinogenesis. The important contributions of γδ
T cells are (i) to perform a protective role in the context of barrier damage and pathogenic
microorganism translocation;(ii) to exert either pro-or anti-inflammatory effects at different …
Increasing evidence suggests that intestinal microbiota dysbiosis and chronic inflammation contribute to colorectal cancer (CRC) development. γδ T cells represent a major innate immune cell population in the intestinal epithelium that is involved in the maintenance of gut homeostasis, inflammation regulation, and carcinogenesis. The important contributions of γδ T cells are (i) to perform a protective role in the context of barrier damage and pathogenic microorganism translocation; (ii) to exert either pro- or anti-inflammatory effects at different inflammatory stages; and (iii) to boost the crosstalk between immune cells and tumor microenvironment, inducing a cascade of suppressive immune responses. Understanding the crucial role of γδ T cells would enable us to manipulate these cells during the CRC sequence and improve the efficacy of tumor therapy.
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