Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro
Z Zhou, J Qi, CW Lim, JW Kim, B Kim - Toxicology, 2020 - Elsevier
The common causes of Non-alcoholic fatty liver disease (NAFLD) are obesity, dyslipidemia,
and insulin resistance. Metabolic disorders and lipotoxic hepatocyte damage are hallmarks
of NAFLD. Even though amlexanox, a dual inhibitor of TRAF associated nuclear factor κB
(NF-κB) activator-binding kinase 1 (TBK1) and IκB kinase epsilon (IKKε), has been reported
to effectively improve obesity-related metabolic dysfunctions in mice models, its molecular
mechanism has not been fully investigated. This study was designed to investigate the …
and insulin resistance. Metabolic disorders and lipotoxic hepatocyte damage are hallmarks
of NAFLD. Even though amlexanox, a dual inhibitor of TRAF associated nuclear factor κB
(NF-κB) activator-binding kinase 1 (TBK1) and IκB kinase epsilon (IKKε), has been reported
to effectively improve obesity-related metabolic dysfunctions in mice models, its molecular
mechanism has not been fully investigated. This study was designed to investigate the …
