The fibroblastic T cell niche in lymphoid tissues
AL Fletcher, AT Baker, V Lukacs-Kornek… - Current Opinion in …, 2020 - Elsevier
Current Opinion in Immunology, 2020•Elsevier
Fibroblastic reticular cells (FRCs) are a necessary immunological component for T cell
health. These myofibroblasts are specialized for immune cell support and develop in
locations where T and B lymphocyte priming occurs, usually secondary lymphoid organs,
but also tertiary lymphoid structures and sites of chronic inflammation. This review describes
their dual supportive and suppressive functions and emerging evidence on the co-ordination
required to balance these competing roles.
health. These myofibroblasts are specialized for immune cell support and develop in
locations where T and B lymphocyte priming occurs, usually secondary lymphoid organs,
but also tertiary lymphoid structures and sites of chronic inflammation. This review describes
their dual supportive and suppressive functions and emerging evidence on the co-ordination
required to balance these competing roles.
Fibroblastic reticular cells (FRCs) are a necessary immunological component for T cell health. These myofibroblasts are specialized for immune cell support and develop in locations where T and B lymphocyte priming occurs, usually secondary lymphoid organs, but also tertiary lymphoid structures and sites of chronic inflammation. This review describes their dual supportive and suppressive functions and emerging evidence on the co-ordination required to balance these competing roles.
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