Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2
L Tai, Q Zheng, S Pan, ZG Jin, BC Berk - Journal of Biological Chemistry, 2005 - ASBMB
Blood flow modulates endothelial cell (EC) functions through specific signaling events.
Previous data show that flow stimulates SHP2 translocation to cell membranes and binding
to phosphotyrosine proteins. Flow-induced ERK1/2 phosphorylation depends on SHP2
phosphatase activity and SHP2 binding to phospho-PECAM1 (platelet endothelial adhesion
molecule 1), suggesting that SHP2 forms a signaling module with PECAM1. We
hypothesized that flow induces assembly of the multi-protein complexes with SHP2 that are …
Previous data show that flow stimulates SHP2 translocation to cell membranes and binding
to phosphotyrosine proteins. Flow-induced ERK1/2 phosphorylation depends on SHP2
phosphatase activity and SHP2 binding to phospho-PECAM1 (platelet endothelial adhesion
molecule 1), suggesting that SHP2 forms a signaling module with PECAM1. We
hypothesized that flow induces assembly of the multi-protein complexes with SHP2 that are …
