[HTML][HTML] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-κB pathway
T Tando, A Ishizaka, H Watanabe, T Ito, S Iida… - Journal of biological …, 2010 - ASBMB
The SWI/SNF chromatin remodeling complex plays pivotal roles in mammalian
transcriptional regulation. In this study, we identify the human requiem protein (REQ/DPF2)
as an adaptor molecule that links the NF-κB and SWI/SNF chromatin remodeling factor.
Through in vitro binding experiments, REQ was found to bind to several SWI/SNF complex
subunits and also to the p52 NF-κB subunit through its nuclear localization signal containing
the N-terminal region. REQ, together with Brm, a catalytic subunit of the SWI/SNF complex …
transcriptional regulation. In this study, we identify the human requiem protein (REQ/DPF2)
as an adaptor molecule that links the NF-κB and SWI/SNF chromatin remodeling factor.
Through in vitro binding experiments, REQ was found to bind to several SWI/SNF complex
subunits and also to the p52 NF-κB subunit through its nuclear localization signal containing
the N-terminal region. REQ, together with Brm, a catalytic subunit of the SWI/SNF complex …