[HTML][HTML] Arid2 regulates hematopoietic stem cell differentiation in normal hematopoiesis
T Bluemn, J Schmitz, Y Chen, Y Zheng, Y Zhang… - Experimental …, 2021 - Elsevier
Highlights•Loss of Arid2 has largely no effect on steady-state hematopoiesis.•Arid2 loss
leads to impairment in lymphoid lineage regeneration.•Arid2 null HSPCs exhibit enrichment
of myeloid-biased MPP signature.•Loss of Arid2 leads to upregulation of inflammatory
pathways.•Arid2 null cells have proliferation defects under lymphoid condition with LPS.The
switch/sugar nonfermenting (SWI/SNF) family of chromatin remodeling complexes have
been implicated in normal hematopoiesis. The ARID2 protein is a component of the …
leads to impairment in lymphoid lineage regeneration.•Arid2 null HSPCs exhibit enrichment
of myeloid-biased MPP signature.•Loss of Arid2 leads to upregulation of inflammatory
pathways.•Arid2 null cells have proliferation defects under lymphoid condition with LPS.The
switch/sugar nonfermenting (SWI/SNF) family of chromatin remodeling complexes have
been implicated in normal hematopoiesis. The ARID2 protein is a component of the …