Go to
JCI Insight
About
Editors
Consulting Editors
For authors
Publication ethics
Publication alerts by email
Advertising
Job board
Contact
100th anniversary
Current issue
Past issues
By specialty
COVID-19
Cardiology
Gastroenterology
Immunology
Metabolism
Nephrology
Neuroscience
Oncology
Pulmonology
Vascular biology
All ...
Videos
Conversations with Giants in Medicine
Author's Takes
Reviews
Reviews
View all reviews ...
Review Series
Vascular Malformations (Apr 2024)
Lung inflammatory injury and tissue repair (Jul 2023)
Immune Environment in Glioblastoma (Feb 2023)
Korsmeyer Award 25th Anniversary Collection (Jan 2023)
Aging (Jul 2022)
Next-Generation Sequencing in Medicine (Jun 2022)
New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
View all review series ...
Viewpoint
Collections
In-Press Preview
Commentaries
Research Letters
Letters to the Editor
Editorials
Viewpoint
JCI This Month
Top read articles
Clinical Medicine
Author's Take
0 Articles
172 Posts
No articles were found with this tag.
← Previous
1
2
…
10
11
12
…
17
18
Next →
SPARCL1 and the colorectal carcinoma microenvironment
In this episode, Michael Stürzl, Elisabeth Naschberger, and Andrea Liebl discuss their study, which identifies endothelial cell secretion of the protein SPARCL1 as an important regulator of colorectal cancer aggressiveness...
Published October 10, 2016
Author's Take
Vascular stiffness drives metabolic alterations in pulmonary hypertension
In this episode, Stephen Chan discusses work from his laboratory that links increased vascular stiffness to altered glutamine metabolism in the pathogenesis of pulmonary hypertension.
Published August 22, 2016
Author's Take
Calpain-6 mediates atherogenic macrophage function
In this episode, Takuro Miyazaki and colleagues reveal that elevation of calpain-6 in macrophages promotes atherogenic functions by disrupting CWC22/EJC/Rac1 signaling.
Published August 15, 2016
Author's Take
Cardiology
Local TNF mediates free cholesterol–dependent podocyte injury
In this episode, Alessia Fornoni reveals that TNF promotes free cholesterol–dependent podocyte apoptosis via an NFATc1/ ABCA1-dependent mechanism.
Published August 2, 2016
Author's Take
Nephrology
p21 contributes to macrophage switching during sepsis
In this episode, Dimitrios Balomenos and Gorjana Rackov discuss their recent study, which shows that p21 is instrumental in macrophage switching from a pro-inflammatory to an immunosuppressive state during sepsis.
Published July 18, 2016
Author's Take
Insight into pathologic epidermal-immune interactions in psoriasis
In this episode, Peter Marinkovich and Mårten Winge discuss their work, which shows that hyperactivation of RAC1 in the skin drives pathogenic interactions between the epidermis and the immune system in psoriasis.
Published June 13, 2016
Author's Take
Breaking down skin barrier function in mice with pruritic dermatitis
In this episode, Hisahiro Yoshida describes the development and characterization of a strain of mice that exhibit progressive pruritic dermatitis...
Published April 25, 2016
Author's Take
Unraveling the role of sex in renal ischemia tolerance
In this episode, Matthew Levine and David Aufhauser discuss their work, which reveals sex-specific effects on renal ischemia tolerance and transplantation outcomes...
Published April 18, 2016
Author's Take
Increasing drug delivery through the blood-brain barrier
In this episode, Margaret Bynoe reveals that activation of the A2A adenosine receptor (A2A AR) with the FDA-approved agonist Lexiscan reversibly reduced expression of the drug efflux transporters P-glycoprotein and BCRP1.
Published April 4, 2016
Author's Take
TLR9 activation in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is the most common liver disease in the US and can lead to cirrhosis, cancer, and death; however, the drivers of NASH development are poorly understood. In this episode, Wajahat Mehal and colleagues reveal that le...
Published January 25, 2016
Author's Take
← Previous
1
2
…
10
11
12
…
17
18
Next →
Advertisement