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Clinical Medicine
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Translating a rodent behavioral assay for humans
While animal models of neurodegenerative diseases exhibit many of the features observed in patients, it remains a challenge to translate laboratory findings to effective clinical therapies. In this episode, Steve Finkbeiner, Pascal Sanchez, and Kate...
Published January 19, 2016
Author's Take
Linking intranasal group A Streptococcus infection to CNS complications
Infection with group A Streptococcus (GAS) causes the common and treatable pharyngitis known as strep throat; however, these infections are also associated with autoimmune diseases of the central nervous system (CNS). A subset of child...
Published December 14, 2015
Author's Take
Protecting positively selected B cell clones from apoptosis
The affinity that B cells have for antigen is increased through an iterative process known as affinity maturation. This process involves the cycling of B cells cycle between somatic hypermutation and proliferation in the germinal center (GC) dark zo...
Published December 14, 2015
Author's Take
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms are endemic to areas with high rates of TB, helminths are thought to enhan...
Published November 16, 2015
Author's Take
Understanding the drivers of granulomatosis with polyangiitis
Granulomatosis with polyangiitis (GPA) is a form of autoimmune vasculitis that is associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs) directed against proteinase 3 (PR3). In this episode, Véronique Witko-Sarsa...
Published October 5, 2015
Author's Take
Addressing the point of no return for gene therapy
Retinitis pigmentosa (RP) is hereditary retinal degenerative disease that is characterized by progressive loss of photoreceptor function. In human trials, gene therapy has been shown to improve vision; however, this benefit has not been sustainable....
Published August 24, 2015
Author's Take
Restoring the neuronal transciptome to improve cognitive decline
Epigenetic modifications, such as histone acetylation, are dysregualted in Alzheimer’s disease (AD) and other neurodegenerative disorders, resulting altered patterns of neuronal gene expression and cognitive decline. In this episode, Eva Benit...
Published August 17, 2015
Author's Take
Maintaining adult hematopoiesis
An inability to properly sustain blood cell production results in the development of hematopoietic disorders. Epigenetic regulators have been shown to be involved in the function of hematopoietic stem and progenitor cells; however, dysfunction of th...
Published August 10, 2015
Author's Take
Pinpointing epidemic group A Streptococcus strain emergence
Group A Streptococcus (GAS) causes a wide array of infections ranging from mild to serious and even life threatening. Epidemic strains of GAS have enhanced virulence; however, the molecular events that allow for widespread disseminati...
Published August 10, 2015
Author's Take
Aerosolized Ebola vaccine protects primates
Ebola virus causes severe hemorrhagic fever and is readily transmitted through contact with or inhalation of aerosolized biological fluids from infected individuals. Vaccines against this deadly virus are currently in development. As Ebola outbreaks...
Published July 13, 2015
Author's Take
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